What Should You Know About VESIcare (Solifenacin)?

VESIcare  Manufactured by: Astellas Pharma US, Inc

VESIcare: VESIcare is an excellent drug to treat incontinence (incontrollable urgency and frequent urination) in both men and women.

What Should You Know About VESIcare?

You should know that this medicine:

  • Is not available over the counter and you should always talk to your doctor about your condition before using the drug.
  • Can easily be ingested before or after a meal.
  • Can cause severe allergic skin reactions. In such conditions you should discontinue VESIcare and seek medical help.
  • Should be used with caution if you have a kidney or a liver problem for which you are already being treated.
  • Can cause sleepiness, headaches and illusions, so you should avoid driving or working after taking VESIcare.
  • Can lead to the progression of abnormal thirst, pain in the stomach, constipation, painful urination.
  • Can cause harmful effects in children, so keep it away from them.
  • Can either cause or worsen the underlying heart conditions, so you should never miss your follow-up with your doctor.

How To Use VESIcare?

Take VESIcare in the prescribed dosage with a glass full of water on an empty stomach or after a meal. While consuming do not open, break or split the tablets. If taking before bedtime, avoid drinking too much water or tea, coffee, alcohol or any other form of beverage.

Do Not Use VESIcare:

  • If you have ever experienced an allergic reaction to the contents present in it.
  • If your doctor has informed you that there is a substantial obstruction in your bladder, or any other such condition that causes retention of the urine.
  • Unless recommended by your healthcare provider if you have any sort of digestive problem.
  • If you start experiencing headache, drowsiness, or visions and talk to you doctor about it.
  • If you have previously been treated for glaucoma (raised fluid pressure in eyes).
  • If you are suffering from a renal or a hepatic deficiency.

Which Side Effects Are Produced By VESIcare?

Normally it causes dry mouth, constipation, blurred vision. Apart from these it can also affect specific organs in the body;

  • Eyes: Blurry vision, dryness in the eyes.
  • Digestive system: Dry mouth, constipation, nausea, indigestion, pain in the abdomen, and vomiting.
  • Nervous system: dizziness, depression.
  • Kidney: infections of the urinary tract, inability to urine.
  • Chest and lungs: cough
  • Vessels: high blood pressure
  • Others: swelling in lower limb, muscle weakness, flu.
  • Post-marketing: rash, headache, weakness in muscles, confusion and dizziness, reduced appetite, fastened heartbeat, increased levels of potassium in the body, kidney failure.

Does VESIcare Interact With The Other Drugs?

VESIcare does not interfere with drugs such as digoxin, warfarin or oral birth control pills.

The VESIcare works in our body can be affected if taken with drugs that either induce or inhibit CYP3A4 enzymes present in our liver and intestines.

CYP3A4 inducers include medicines like glucocorticoids, phenytoin, rifabutin, progesterone etc. The drugs that can inhibit CYP3A4 are clarithromycin, cyclosporine, cimetidine, azoles etc.

*Consult your community pharmacist to know which drugs are inhibitors or inducers of these enzymes.

Can This Drug Be Used In The Specific Populations?

  • In pediatrics: This drug can be harmful to children.
  • In geriatrics: VESIcare should be avoided in elderly having kidney and liver problems.
  • During pregnancy: It belongs to the category C which means that animal studies have shown risks to the unborn baby and human studies are yet to be established. Its use should only be limited when no other alternatives are present.
  • During lactation: It hasn’t been determined whether this drug gets secreted in human milk, therefore, avoid its use during breast feeding.

 

Pharmacology Of VESIcare: How Does This Drug Work?

It reduces the spasm of the bladder muscles and the urinary tract muscles by competitively inhibiting the muscarinic-receptors present in the urinary system. The neurotransmitter acetylcholine, upon interaction with its receptors, contracts the bladder and empties it. The goal of this drug is to inhibit these receptors and reduce the contraction of the muscles present in the bladder and increase the retention capacity of the bladder.

What Is The Pharmacokinetics Of This Drug?

Pharmaco-kinetics is what the body does to a drug. It includes the following factors:

Absorption: 90% of solifenacin enters the blood circulation once a tablet of VESIcare is swallowed.

Distribution: It has a distribution volume of 600L and almost 98% of Solifenacin binds to human plasma proteins. The drug shows its affects after sometime because only the free unbound drug can enter the tissues and bind to the receptors.

Metabolism and Elimination: Its metabolism takes place in the liver and as result about 69.2% of the drug is excreted in the urine and about 22.5% by the feces.

Pharmacokinetics Of The Drug And Population

There is no evident change in the interaction of this drug in different populations, it’s metabolism is same in all genders

What Is The Toxicology Profile Of This Drug?

The reproductive system was not harmed by VESIcare and it didn’t show any carcinogenic properties i.e., no cancer producing or mutagenic properties were observed during the pre-clinical trials.

What Should You Tell Your Doctor Before Using VESIcare?

Inform your doctor about:

  • Any eye-related problems
  • Previous liver or kidney injuries (if any)
  • If you have a mechanical obstruction in your gastric tract
  • Any cardiovascular issues
  • If pregnant or breast feeding a child

What Are The Ingredients Used In These Tablets?

  • Active Ingredient: solifenacin succinate
  • Inactive Ingredients: lactose monohydrate, corn starch, hypromellose 2910, magnesium stearate, talc, polyethylene glycol 8000 and titanium dioxide with yellow ferric oxide (5 mg VESIcare tablet) or red ferric oxide.

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