A compound known as lipoic acid supplement (LAS) may help in losing weight for an obese but otherwise healthy individual, says a recent study conducted by the researchers from the Oregon State University (OSU) and the Oregon Health & Science University (OHSU). The findings of the study have been published in the Journal of Nutrition (JN).
Lipoic Acid Supplements Help Overweight People Lose Weight in Clinical Trial – SciTechDaily https://t.co/sONihjP34m
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To check the functioning of the LAS, the team aimed at a sample comprised of 31 overweight but otherwise healthy people. The researchers did a comparison of 31 overweight healthy people with another placebo group with the same sample size.
The investigators administered a 600-milligram dose of LAS for consecutive 24 weeks on overweight healthy participants. Overwightedness or obesity is referred to as a condition in which the body mass index (BMI) is increased to 30 or above that results in a production of a high level of fatty acids and low-grade inflammation in the body.
Body Mass Index (BMI) is an individual’s weight in kilograms divided by the square of height in meters. A high BMI can be an indicator of high body fatness. Experts suggest aiming for a normal body mass index (BMI) between 18.5 to 24.9. If the range goes up to 30 to 39.9, then sadly, you’re considered to be obese and likely to develop High Blood Pressure (HBP) and DM.
Furthermore, obese individuals have hypersecretion of insulin that increases the risk of hyperglycemia and diabetes mellitus (DM).
How Does LAS Work?
LAS is a natural protective antioxidant, also known as thiotic acid that can be synthesized by many plants and animals. The human body can also produce LAS. Lipoic acid has a molecular bond that bound with certain proteins, which function as part of those essential mitochondrial multienzyme complexes which involved in energy and amino acid metabolism. Furthermore, the acid has two sulfur atoms at one end of the chain which is used for the transmission of electrons from other sources.
Functions of LAS: It has been found that when the LAS has taken as a dietary supplement, it results in three responses including stimulation of glucose metabolism, antioxidant defenses, and anti-inflammatory responses. These findings suggested that LA supplements can be used for the treatment of various life-threatening diseases such as age-related poor thinking patterns, cardiovascular diseases, and DM.
Previous researches on Rodents and human trials have found that the use of LAS is beneficial for three of the underlying conditions including lipoic acid on oxidative stress, lipid metabolism, and circadian rhythm, mentioned by Alexander Michels, another Linus Pauling Institute (LPI) scientist involved with the study. The team found a mild reduction in oxidative stress in people who have taken LAS during trials.
Two Main Issues Ignored in Previous Clinical Trial of LAS
Hagen, principal investigator and Helen P. Rumbel Professor for Healthy Aging Research at the institute have addressed two main issues involved in the previous human trials of LAS:
- When it comes to testing the effectiveness of LAS, many researchers made a mistake by focusing only on those participants who are suffering from diseases such as DM which made it difficult to analyze the clinical efficacy of the use of LAS.
- The second issue is the formulation of LAS. Researchers from previous studies often used the S form of LA which is a product of industrial synthesis and not found in nature. On another hand, the present study involved the R form of LA which can be naturally found in the body.
The researchers have also determined that triglycerides which are a type of lipid in the blood, were not significantly found in those study participants who were taking the doses of LAS. It has also been found a clear cut reduction in the triglycerides in those people who used LAS and decreased weight during the clinical trials.
Hegan added: Identifying which patients will benefit the most from lipoic acid supplementation, and how much they need, is important for both clinical and economic reasons. Lipoic acid supplements are often quite expensive. So understanding how we can maximize benefits with smaller amounts of the supplement is something we are interested in pursuing.”
The overall findings of the present study suggested that LAS can be useful in weight loss for overweight or obese but otherwise healthy people.