There are numerous topical systematic therapies available for the management of diabetic foot wounds, including standard management techniques such as wound care. However, a therapy called Cold Atmospheric Plasma Therapy (CAPT) has shown its effectiveness in decreasing bacterial load in chronic wounds.
To check its feasibility on diabetic foot ulcers (DFU), researchers recently conducted a randomized clinical trial and found positive outcomes in treating patients with DFU. The findings of the study have bee published in the Journal of the American Medical Association (JAMA): Diabetes and Endocrinology.
— JAMA Network Open (@JAMANetworkOpen) July 16, 2020
— ClinOwl Endocrinology (@Clin_Owl_Endo) July 16, 2020
For the study purpose, a research team from Germany has conducted a prospective, randomized, placebo-controlled, patient-blinded clinical trial in which the team recruited 43 patients that had a total of 62 diabetic foot ulcers which is a common but complex disease that can occur in the skin, muscles, and bones of the foot due to the nerve damage, poor blood circulation, high blood pressure (HBP) and/or infection or injuries that are associated with diabetes.
An estimated 463 million adults (20-79 years) are living with Diabetes mellitus (DM) whereas the annual rate of DFU is around 2% to 5% of the total population and the lifetime risk has lied between 15% to 20% according to a paper published in The US National Center for Biotechnology Information (NCBI).
Management of the diabetic foot requires a thorough knowledge of the major risk factors for amputation, frequent routine check-ups, and preventive maintenance. So, to prevent the wounds of the patients with DFU, the team used CAPT which is a novel technique highly used in biomedicine. This therapy helps the patients to secure themselves from new infections in the hospital setting. It works by spinning off from space hardware knocks out bacteria without damaging human tissue, thereby accelerating the process of wound healing.
After the administration of CAPT on study participants, the compared the outcomes of CAPT with the other standard treatment that is currently being used for patients of DFU.
Standard Management Care for DFU Patients
Standard treatments for DFU patients include wound care, prevention of the ulcer, ‘off-loading’ that can be defined as taking the pressure off from the infected spot then remove the dead skin or tissue where the infection has taken place. Removal of the infection is referred to as ‘debridement’. The last step after applying medication on the wound is to manage HBP, high glucose level, and other co-occurring situations that can trigger the disease again.
The current trial has been conducted at two different clinics from 17, 2016, to April 20, 2019, and the demographics and contributing variables including sex, smoking status, and age were also assessed. The researchers divided the data into two groups. The first CAP group had 29 patients with 33 wounds whereas the second placebo group had 28 patients with 32 wounds.
The team administered 8 applications of Standard care treatment with either CAP generated from argon gas in an atmospheric pressure plasma jet or 8 applications of placebo treatment in a control group for the further comparison.
Findings: After the compilation of the measure from both groups, the German investigators have found that 16.1% and 13% from the CAP group and placebo group were active smokers. They also determined that the CAP group had more speedy wound recovery than the controlled group with no adverse effects of both have found treatment in both groups.
CAP therapy that has previously been very effective in treating chronic infections, managing cancer cells, and also dental infections is now showing its positive results in healing the infected wounds of diabetic ulcers.