Deteriorating immune system and increasing death rate are two major complications that an individual faces with increasing age. Yet, some of the complications can be reversed, as researchers have demonstrated in an animal model that these two age-related impairments can be halted and even partially reversed using a novel cell-based therapeutic approach.
Age-related impairments reversed in animal model https://t.co/iXEQBZbZo6
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Elderly people are more vulnerable to infectious diseases because of power immune system that is continuously declining with progressing age. This presumption has become more affirmative during seasonal influenza outbreaks or the occurrence of other viral diseases such as COVID-19. As the vaccine viability at the old age is diminished gradually as this age group is most vulnerable to contract the infectious pathogens and frequently shows the most noteworthy death rate. Notwithstanding the age-related immune decline aged individuals are commonly affected by frailty that negatively impacts quality-of-life. Even though the average life-expectancy for humans continuous to rise, living longer is often associated with age-related health issues.
Adipose tissue eosinophils (ATEs) are essential to control the obesity and associated inflammation, that if not controlled leads to serious metabolic disease. However, the way in which ageing impacts the role of ATEs was not clear. Yet, in the current study, it was found that ATEs undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis – a mechanism to keep things normal inside the body, and systemic low-grade inflammation in both humans and mice.
The research team of Dr. Noti and Dr. Eggel explained that specific immune cells called eosinophils, abundantly found in circulating blood, are also found in belly fat of both humans and mice. These cells are known typically for providing protection against pathogens such as parasites who promote allergic airway disease. The eosinophils located in belly fat then protect against these parasites by maintain immune homeostasis locally. The research study states that with increasing age the frequency of eosinophils in belly fat declines, yet the number of pro-inflammatory macrophages – another immune cells, increases. Owing to this immune cell imbalance, the belly fat turns into a source of pro-inflammatory mediators that accumulate at the time of old age.
Following, after the researchers investigated the immune cells role in belly fat, they investigated the possibility to reverse age-related impairments by restoring the immune cell balance in visceral adipose tissue.
“In different experimental approaches, we were able to show that transfers of eosinophils from young mice into aged recipients resolved not only local but also systemic low-grade inflammation,” says Dr. Eggel.
He further added, “A future direction of our research will be to now leverage the gained knowledge for the establishment of targeted therapeutic approaches to promote and sustain healthy aging in humans,” says Dr. Eggel.