Study Underway to Find Link Between COVID-19 and Pediatric Multisystem Inflammatory Syndrome

Scientists have found that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a link with a rare pediatric syndrome, known as multisystem inflammatory syndrome in children (MIS-C). But, the exact cause of this disease is still unknown.

The researchers are now conducting a study to find a link and risk factors between COVID-19 and MIS-C. The study has been entitled ‘PreVAIL kIds” which means Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence. The research will be funded by the National Institutes of Health (NIH).

A study on a project of PreVAIL kIds that could successfully find out the correlation between MIS-C and COVID-19 will be awarded 20$ million by NIH. PreVAIL kIds project is part of NIH’s Rapid Acceleration of Diagnostics (RADx) initiative to speed innovation in the development, commercialization, and implementation of technologies for COVID-19 testing.

The condition MIS-C is a rare but severe condition. The common symptoms include fever and so many other symptoms including abdominal pain, vomiting, diarrhea, neck pain, rash, bloodshot eyes, tiredness, or fatigued. The disease can result in inflammation in various body parts including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs.

According to a paper published by the Centers for Disease Control and Prevention (CDC) has reported a total of 570 and 10 confirmed cases and fatalities, respectively, have been reported by MIS-C in 40 different states of Washington, DC, and New York City.

Source: CDC
Source: CDC: Age of MIS-C Reported Cases

The symptoms of MIS-C appear after two to four weeks after catching the deadly coronavirus that has caused a huge disaster by taking nearly 724,000 lives. The virus has infected more than 19.5 million people around the globe.

While the virus has made huge destruction throughout the world, more than 11.7 million people have successfully fought against the coronavirus and recovered, according to the data excluded from two main resources including Johns Hopkins University (JHU) live update about coronavirus and Worldometer.

Source: Worldometer

The aim of the new study is to find out those symptoms of COVID-19 that will lead a patient towards MIS-C. The focus of the attention of the researchers will be on those areas and factors that will trigger both of the diseases including COVID-19 and MIS-C such as genetic, immune, viral, and environmental factors. Later on, the team will develop the therapeutic interventions that can differentiate the coronavirus from MIS-C. So, the researchers can treat the new, rare, and severe disease separately.

Diana W. Bianchi, M.D., director of NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) said:

“We urgently need methods to distinguish children at high risk for MIS-C from those unlikely to experience major ill effects from the virus, so that we can develop early interventions to improve their outcomes”.

The Study Criteria: The researchers will enroll the data in which those participants included that will have no symptoms at all to fever and cough, abdominal pain and diarrhea, and inflammation of the coronary arteries. The team will use artificial intelligence and machine learning techniques to find the leading ways from which the virus could enter and interacts with the host to damage the immune system.

Furthermore, after determining every risk factor of MIS-C, the team will head towards the next step of developing the conventional treatment and therapeutic intervention to overcome the new disease.

WHO Guidelines to Protect Kids from COVID-19

World Health Organization (WHO) has issued new guidelines for the parents and caregivers for the safety of kids as well as to stop the transmission of the virus.

Source: Royal College of Pediatrics and Child Health

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